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1 article(s) from Kandasamy, Gayathri

Poly(1-vinylimidazole) polyplexes as novel therapeutic gene carriers for lung cancer therapy

Gayathri Kandasamy,
Elena N. Danilovtseva,
Vadim V. Annenkov and
Uma Maheswari Krishnan

Beilstein J. Nanotechnol. 2020, 11, 354–369, doi:10.3762/bjnano.11.26

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Figure 1: (A) Gel retardation assay for polyplexes formed with different ratios (v/v) of PVI/siRNA. Ethidium ...

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Figure 2: (A) FTIR spectra of free siRNA, PVI and the polyplex recorded in ATR mode between 4000 and 400 cm⁻¹...

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Figure 3: (A) Intracellular uptake of the polyplex monitored by using laser scanning confocal microscopy afte...

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Figure 4: The endosomal escape of the polyplex after 4 h of incubation in A549 cells visualized using endotra...

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Figure 5: Expression of vascular endothelial growth factor (VEGF) mRNA in A549 cells analyzed by RT-PCR. The ...

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Figure 6: VEGF, HIF-1alpha and β-actin protein expression levels, obtained from Western blot, in A549 cells a...

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Figure 7: Cell viability of A549 cancer cells after treatment with carrier systems (blank carrier and the pol...

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Figure 8: Flow cytometry analysis of A549 cells treated for 4 h with VEGF siRNA and analyzed 48 h after treat...

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Figure 9: Morphology of A549 cells after treatment with blank PVI nanoparticles or polyplex. (A) Control; (B)...

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Figure 10: (A) Migration of A549 cells 48 h after treatment with free siRNA, blank polymer nanoparticles, poly...

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Figure 11: (A) Migration of A549 cells analyzed using Boyden chamber assay 48 h after treatment. a: Control; b...

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Figure 12: Viability of A549 cells after silencing VEGF using free siRNA or the polyplex for 4 h followed by t...

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Figure 13: Morphology of HUVECs cultured in serum-free medium after (A) 0 h, (B) 24 h, and (C) 48 h; (D) contr...

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Figure 14: (A): Hierarchical clustering obtained from the microarray analysis (49,372 genes). Each row represe...

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Published 17 Feb 2020

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